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Mediator

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Revision as of 16:25, 20 October 2017 by Joel L. Sussman (Talk | contribs)
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Yeast mediator head module Med7 (grey) and Med21 (green) (PDB entry 1yke)

Drag the structure with the mouse to rotate

3D structures of mediator

3rj1 – Med6 + Med8 + Med11 + Med17 + Med18 + Med20 + Med22 - yeast
1yke, 1ykh – Med7 + Med21
3fbi, 3fbn – Med7 N terminal + Med31
3c0t - Med8 C terminal + Med18
2hzs – Med8 C terminal + Med18 + Med20
3r84 - Med11 + Med22 (mutant)
2lpb - Med15 + general control protein GCN4
2hzm – Med18 + Med20
2l23, 2l6u, 2ky6, 2xnf – Med25 activator-interacting domain - NMR



References

  1. Imasaki T, Calero G, Cai G, Tsai KL, Yamada K, Cardelli F, Erdjument-Bromage H, Tempst P, Berger I, Kornberg GL, Asturias FJ, Kornberg RD, Takagi Y. Architecture of the Mediator head module. Nature. 2011 Jul 3;475(7355):240-3. doi: 10.1038/nature10162. PMID:21725323 doi:10.1038/nature10162
  2. Taatjes DJ. The human Mediator complex: a versatile, genome-wide regulator of transcription. Trends Biochem Sci. 2010 Jun;35(6):315-22. Epub 2010 Mar 17. PMID:20299225 doi:10.1016/j.tibs.2010.02.004
  3. 3.0 3.1 Imasaki T, Calero G, Cai G, Tsai KL, Yamada K, Cardelli F, Erdjument-Bromage H, Tempst P, Berger I, Kornberg GL, Asturias FJ, Kornberg RD, Takagi Y. Architecture of the Mediator head module. Nature. 2011 Jul 3;475(7355):240-3. doi: 10.1038/nature10162. PMID:21725323 doi:10.1038/nature10162

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Bradley Altier, Alexander Berchansky

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