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1okx
From Proteopedia
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BINDING STRUCTURE OF ELASTASE INHIBITOR SCYPTOLIN A
Overview
Natural bioactive compounds are of general interest to pharmaceutical, research because they may be used as leads in drug development campaigns., Among them, scyptolin A and B from Scytonema hofmanni PCC 7110 are known, to inhibit porcine pancreatic elastase, which in turn resembles the, attractive drug target neutrophil elastase. The crystal structure of, scyptolin A as bound to pancreatic elastase was solved at 2.8 A, resolution. The inhibitor occupies the most prominent subsites S1 through, S4 of the elastase and prevents a hydrolytic attack by covering the active, center with its rigid ring structure. The observed binding structure may, help to design potent elastase inhibitors.
About this Structure
1OKX is a Protein complex structure of sequences from Scytonema hofmanni and Sus scrofa. Active as Pancreatic elastase, with EC number 3.4.21.36 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Binding structure of elastase inhibitor scyptolin A., Matern U, Schleberger C, Jelakovic S, Weckesser J, Schulz GE, Chem Biol. 2003 Oct;10(10):997-1001. PMID:14583266
Page seeded by OCA on Tue Dec 18 17:48:54 2007
