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Structural highlights

Function

MYO7B_HUMAN Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. May link the complex to the actin core bundle of microvilli (Probable).^{[1] [2]}

See Also

• Harmonin
• Myosin 3D Structures

References

1. ↑ Crawley SW, Shifrin DA Jr, Grega-Larson NE, McConnell RE, Benesh AE, Mao S, Zheng Y, Zheng QY, Nam KT, Millis BA, Kachar B, Tyska MJ. Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesion. Cell. 2014 Apr 10;157(2):433-46. doi: 10.1016/j.cell.2014.01.067. PMID:24725409 doi:http://dx.doi.org/10.1016/j.cell.2014.01.067
2. ↑ Crawley SW, Weck ML, Grega-Larson NE, Shifrin DA Jr, Tyska MJ. ANKS4B Is Essential for Intermicrovillar Adhesion Complex Formation. Dev Cell. 2016 Jan 25;36(2):190-200. doi: 10.1016/j.devcel.2015.12.022. PMID:26812018 doi:http://dx.doi.org/10.1016/j.devcel.2015.12.022