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2cyx
From Proteopedia
Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7)
Overview
The human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7) is involved in protein degradation, including a process known as endoplasmic reticulum-associated degradation (ERAD). The crystal structure of human UBE2G2/UBC7 was solved at 2.56 angstroms resolution. The UBE2G2 structure comprises a single domain consisting of an antiparallel beta-sheet with four strands, five alpha-helices and two 3(10)-helices. Structural comparison of human UBE2G2 with yeast Ubc7 indicated that the overall structures are similar except for the long loop region and the C-terminal helix. Superimposition of UBE2G2 on UbcH7 in a c-Cbl-UbcH7-ZAP70 ternary complex suggested that the two loop regions of UBE2G2 interact with the RING domain in a similar way to UbcH7. In addition, the extra loop region of UBE2G2 may interact with the RING domain or its neighbouring region and may be involved in the binding specificity and stability.
About this Structure
2CYX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7)., Arai R, Yoshikawa S, Murayama K, Imai Y, Takahashi R, Shirouzu M, Yokoyama S, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt, 4):330-4. Epub 2006 Mar 25. PMID:16582478 Page seeded by OCA on Sat May 3 23:22:07 2008
Categories: Homo sapiens | Single protein | Ubiquitin--protein ligase | Arai, R. | Imai, Y. | Murayama, K. | RSGI, RIKEN Structural Genomics/Proteomics Initiative. | Shirouzu, M. | Takahashi, R. | Yokoyama, S. | Yoshikawa, S. | Ligase | National project on protein structural and functional analyse | Nppsfa | Riken structural genomics/proteomics initiative | Rsgi | Structural genomic | Ubl conjugation pathway
