2r7e is a cool protein.
Structural highlights
2r7e is a 2 chain structure found in humans. It has 5 associated ligands ( , , BMA, MAN, NAG) and is coded for by 2 different genes, F8 and F8C. 2r7e has both http://www.uniprot.org/uniprot/P00451 and beta pleated sheet secondary structure. Alterations in this structure can lead to improper location of ligands, leading to failed protein function.
Ligands
2r7e has 5 ligands, which are binding sites for other proteins in Coagulation Factor VIII
Function
2r7e is a protein that makes up part of Coagulation Factor VIII, which is a protein complex involved in blood clotting in humans. Coagulation Factor VIII works with calcium and phosholipids to Factor X to its activated form Xa.
Disease
Mutations in 2r7e can alter the structure of Coagulation Factor VIII, leading to hemophilia a.
Relevance
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
