Sandbox Reserved 1321

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This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430.

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Contents 1 2r7e Overview 2 Ligands 3 Function 4 Disease 5 Relevance 6 References

2r7e Overview

spinqualitylabelsall models 2r7e 3-D Structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image 2r7e is a cool protein. Structural highlights 2r7e is a 2 chain structure found in humans. It has 5 associated ligands ( , , BMA, MAN, NAG) and is coded for by 2 different genes, F8 and F8C. 2r7e has both and

secondary structure. Alterations in this structure can lead to improper location of ligands, leading to failed protein function.

Ligands

2r7e has 5 ligands, which are binding sites for other proteins in Coagulation Factor VIII

Function

2r7e is a protein that makes up part of Coagulation Factor VIII, which is a protein complex involved in blood clotting in humans. Coagulation Factor VIII works with calcium and phosholipids to Factor X to its activated form Xa.

Disease

Mutations in 2r7e can alter the structure of Coagulation Factor VIII, leading to hemophilia a.

Relevance

Yay!

References

h http://www.uniprot.org/uniprot/P00451