Structural highlights
Function
[JZTX5_CHIGU] Inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium channels (Nav) in rat dorsal root ganglion neurons. Highly inhibits Kv4.2/KCND2 and Kv4.3/KCND3 potassium channels and weakly inhibits Kv2.1/KCNB1 potassium channels. The toxin shifts the activation curves to more depolarized potentials. Also binds to phospholipid membranes.[1] [2] [3] [4]
References
- ↑ Yuan C, Yang S, Liao Z, Liang S. Effects and mechanism of Chinese tarantula toxins on the Kv2.1 potassium channels. Biochem Biophys Res Commun. 2007 Jan 19;352(3):799-804. Epub 2006 Nov 27. PMID:17150181 doi:http://dx.doi.org/10.1016/j.bbrc.2006.11.086
- ↑ Zeng X, Deng M, Lin Y, Yuan C, Pi J, Liang S. Isolation and characterization of Jingzhaotoxin-V, a novel neurotoxin from the venom of the spider Chilobrachys jingzhao. Toxicon. 2007 Mar 1;49(3):388-99. doi: 10.1016/j.toxicon.2006.10.012. Epub 2006, Nov 6. PMID:17157888 doi:http://dx.doi.org/10.1016/j.toxicon.2006.10.012
- ↑ Chen J, Deng M, He Q, Meng E, Jiang L, Liao Z, Rong M, Liang S. Molecular diversity and evolution of cystine knot toxins of the tarantula Chilobrachys jingzhao. Cell Mol Life Sci. 2008 Aug;65(15):2431-44. PMID:18581053 doi:http://dx.doi.org/10.1007/s00018-008-8135-x
- ↑ Cai LJ, Xu DH, Luo J, Chen RZ, Chi YP, Zeng XZ, Wang XC, Liang SP. [Inhibition of Jingzhaotoxin-V on Kv4.3 channel]. Sheng Li Xue Bao. 2010 Jun 25;62(3):255-60. PMID:20571743
