User:Tanner Young/Sandbox 1

From Proteopedia

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Structure

is a protein that consists of 403-amino acids. Breaking it down into two main parts (the C-terminal and the N-terminal) it has 166 residues on the C-terminal (C2 Domain) and 179 on the N-terminal (Phosphatase Domain). PTEN is consisted of Alpha helix and Beta pleated sheets.

Jmol ^[1] to the rescue.

1 Function
2 Disease
3 Relevance
4 Structural highlights

Function

PTEN is a dual phosphatase and tumor suppressor protein that interacts with LKB-1. It is composed of a C-terminal and N-Terminal. The C-Terminal is a C2 Domain, this targets proteins to cell membranes. The N-terminal is a Phosphatase Domain, it’s job is to remove phosphate groups from a phosphorolated amino acid.

Disease

The protein is located on the 10th chromosome 10q23.31 in humans. PTEN works with tumor suppressing for cancers, such as breast and prostate cancer. It also works to remove phosphate groups from specific amino acids, such as dephosphorylating tyrosine, serine, and threonine phosphorylated peptides.

Relevance

PTEN’s relevance is that without the PTEN suppressing tumors, you would have a higher increased odds of having multiple cancers, including but not limited to Breast and Prostate cancer.

Structural highlights

References

↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644