User:Ricardo Alberto Chiong Zevallos/Sandbox 1

This is a default text for your page Ricardo Alberto Chiong Zevallos/Sandbox 1. Click above on edit this page to modify. Be careful with the < and > signs.

You may include any references to papers as in: the use of JSmol in Proteopedia ^[1] or to the article describing Jmol ^[2] to the rescue.

Urgente: nesse link eu coloquei os artigos para procurar os detalhes estruturais, ainda não entendi como pegar a estrutura isolada da BMI1 (sem as outras que formam o complexo PRC1) e mostrar no pymol: https://drive.google.com/drive/folders/1l195aNuY6joOd74GKKxa-XWTRMBv_uWF?usp=sharing

pode apagar esse recado depois que você ler, vou deixar o link nas referências

Function

BMI1 is a ring finger protein that is component of a Polycomb group (PcG) multiprotein PRC1-like complex, which epigenetically repress regulatory genes, such as Hox genes, related to embryonic development and self-renewal of somatic stem-cells. BMI1 is central in the DNA damage repair, being the aberrant expression associated with numerous cancers and resistance to some types of chemotherapies.

PcG PRC1-like is responsible for chromatin remodeling and histone modification, mediating monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. BMI1 regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2, which is also a protein component of the PcG PRC1-like complex. In the complex, BMI1 and RING2 form a heterodimer and only RING2 interacts with UbcH5c, wich is a Ubiquitin Conjugating Enzyme E2.

Disease

Relevance

Structure

In the PRC1 complex, Bmi1 and Ring1b heterodimerize via their N-terminal RING domains, forming an active E3 ubiquitin ligase.

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.