6ake

Structural highlights

Function

[CLD3_MOUSE] Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.^[1] [ELTB_CLOPF] This enterotoxin is responsible for many cases of a mild type of food poisoning.

References

1. ↑ Kubota K, Furuse M, Sasaki H, Sonoda N, Fujita K, Nagafuchi A, Tsukita S. Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions. Curr Biol. 1999 Sep 23;9(18):1035-8. PMID:10508613