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Function
Burkholderia species produce oxalate which helps maintain environmental pH. Two enzymes are required to produce oxalate, ObcA and ObcB. ObcA catalyzes first, resulting in a tetrahedral C6-CoA adduct from acetyl-CoA and oxaloacetate. ObcB then produces three products from the C6-CoA adduct which include oxalate, acetoacetate, and CoA. In Burkholderia thailandensis and Burkholderia pseudomallei Obc1 carries out both steps of this reaction as it is a single bi-functional enzyme.
Disease
Burkholderia species have many pathogenic consequences for plants and humans. B. cepacia effects immunocompromised individuals that may have cystic fibrosis or chronic granulomatous disease. B. pseudomallei causes a lethal infection called melioidosis that results in formation of abscesses. In plants, B. glumae causes bacterial panicle blight in rice.
Relevance
Structural highlights
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