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You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
Function
The organism PLpro is from is Coronaviruses. IBV PLpro performs deubiquitination with catalytic efficiencies that are different from other PLpros. Papain-like protease (PLpro) of coronaviruses (CoVs) carries out proteolytic maturation of non-structural proteins that play a role in replication of the virus and performs deubiquitination of host cell factors to scuttle antiviral responses. The substrates and products are PLpro and ubiquitin.
Disease
A disease associated with the protein is avian infectious bronchitis in poultry. The protein helps out with scuttling antiviral responses and when this protein is working it stops the host(chicken) from being able to keep the virus from replicating. Other diseases associated with PLpro include respiratory tract infections and uro-gential tract infections.
Relevance
The results from this experiment can be used to help develop antivirals for the chickens and other animals affected by this virus. This will in turn also help save the poultry industry from facing a huge economic loss every year. Since ubiquitination is not limited to immune responses, PLpros are probably capable of modulating other aspects of the host cell regulated by ubiquitination meaning their impact on the cells goes beyond just this and should be explored further.
Structural highlights
Here is a of PLpro, it's main secondary features are
In this cartoon view the most important tertiary and quaternary structures of PLpro are highlighted
This is a space filling view of PLpro and it provides a view
Here is a hydrophobicity-focused view of PLpro, the importance of hydrophobic and hydrophilic regions are that they
Here is a view of the ligand. The important chemical features of the ligand are
This is the catalytic triad and it helps the protein achieve its function by
The active site is pictured here and has the key amino acids highlighted. Those key amino acids are .
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This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
