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Publication Abstract from PubMed

Membrane localization domain (MLD) was first proposed for a 4-helix-bundle motif in the crystal structure of the C1 domain of Pasteurella multocida toxin (PMT). This structure motif is also found in the crystal structures of several clostridial glycosylating toxins (TcdA, TcdB, TcsL, and TcnA). The Ras/Rap1-specific endopeptidase (RRSP) module of the multifunctional autoprocessing repeats-in-toxins (MARTX) toxin produced by Vibrio vulnificus has sequence homology to the C1-C2 domains of PMT, including a putative MLD. We have determined the solution structure for the MLDs in PMT and in RRSP using solution state NMR. We conclude that the MLDs in these two toxins assume a 4-helix-bundle structure in solution. This article is protected by copyright. All rights reserved.

The membrane localization domains of two distinct bacterial toxins form a 4-helix-bundle in solution.,Hisao GS, Brothers MC, Ho M, Wilson BA, Rienstra CM Protein Sci. 2016 Dec 15. doi: 10.1002/pro.3097. PMID:27977897^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.