Function
7,8-dihydro-8-oxoguanine triphosphatase (DGTP) converts 8-oxoguanine containing deoxyribonucleoside triphosphate to the corresponding monophosphate. DGTP controls spontaneous mutagenesis caused by exogenous oxygen radicals. The E. coli DGTP is called MutT. The human DGTP is called MTH1.[1] For details on MTH1 see Student Project 7 for UMass Chemistry 423 Spring 2015.
Relevance
The 8-oxo-dGTP (oxoG) is a potentially mutagenic substrate when incorporated into DNA.
Structural highlights
- of DGTP (PDB code 3zr0).[2] Water molecules are shown as red spheres.
- .
3D structures of 7,8-dihydro-8-oxoguanine triphosphatase
7,8-dihydro-8-oxoguanine triphosphatase 3D structures
