Sandbox Reserved 1485

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This Sandbox is Reserved from 06/12/2018, through 30/06/2019 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1480 through Sandbox Reserved 1543.
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KAP-1

KAP-1 (KRAB – associated protein 1) is a protein of the KRAB protein family (Krüppel-associated box). These KRAB domain is a domain of repression which is encoded by many zinc finger protein-based transcription factors (KRAB zinc finger proteins or KRAP-ZFPs proteins). KAP-1 is also known as Tripartite motif-containing 28 (TRIM28) and as transcriptional intermediary factor 1β (TIF1β). Indeed, KAP-1 is one of the TRIM proteins (wich code for TRIM genes). Among these TRIM proteins, there is the TIF1 family proteins, of which is part KAP-1 (that’s why KAP-1 is also known as TIF1β and TRIM28). KAP-1 is localized in the nucleus and interacts whith specific regions of the chromatin. This protein plays role in many phenomena as the regulation of transcription, the cellular differenciation and proliferation or even the reparation of DNA damages. Sumoylation can activate the protein in many of its mechanisms while phosphorylation can deactivate the protein.

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References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
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