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Function
Relevance
While the function of cytochrome b2 is to couple L-lactate dehydrogenation to cytochrome c reduction; the mutant ARG289LYS is changing the kinetics of the reactions. It is rising the Ki of several components in comparison to the wild-type, while kcat and KM are also changed by a factor of 10. It changes also the induction by L-lactate.
R289K-b(2)
eing a component of the mitochondrial inter membrane space
Structural highlights
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