From Proteopedia
proteopedia link proteopedia link X-Ray structure of human Serine/Threonine Kinase 17B (STK17B) aka DRAK2 in complex with ADP obtained by on-chip soaking
Structural highlights
6qf4 is a 1 chain structure. Full crystallographic information is available from OCA . For a guided tour on the structure components use FirstGlance . Ligands: , , , , Related: 6qf1 , 6qf2 , 6qf3 Activity: Non-specific serine/threonine protein kinase , with EC number 2.7.11.1 Resources: FirstGlance , OCA , PDBe , RCSB , PDBsum , ProSAT
Function
[ST17B_HUMAN ] Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.[1]
References
↑ Sanjo H, Kawai T, Akira S. DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. J Biol Chem. 1998 Oct 30;273(44):29066-71. PMID:9786912
Categories : Large Structures Non-specific serine/threonine protein kinase Barthelmess, M Bergtholdt, J Burkhardt, A Cerv, M Chapman, H N Crosas, E Fischer, P Guenther, S Kreida, S Lane, T J Lieske, J Lorbeer, O Mariani, V Meents, A Pakendorf, T Ross, B H Schoen, S Seine, T Tornroth-Horsefield, S Yefanov, O Adp Drak2 On-chip ligand soaking Stk17b Transferase
