9ant
From Proteopedia
ANTENNAPEDIA HOMEODOMAIN-DNA COMPLEX
Overview
Homeodomains are one of the key families of eukaryotic DNA-binding motifs and provide an important model system for studying protein-DNA interactions. We have crystallized the Antennapedia homeodomain-DNA complex and solved this structure at 2.4 A resolution. NMR and molecular dynamics studies had implied that this homeodomain achieves specificity through an ensemble of rapidly fluctuating DNA contacts. The crystal structure is in agreement with the underlying NMR data, but our structure reveals a well-defined set of contacts and also reveals the locations and roles of water molecules at the protein-DNA interface. The synthesis of X-ray and NMR studies provides a unified, general model for homeodomain-DNA interactions.
About this Structure
9ANT is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.
Reference
Comparison of X-ray and NMR structures for the Antennapedia homeodomain-DNA complex., Fraenkel E, Pabo CO, Nat Struct Biol. 1998 Aug;5(8):692-7. PMID:9699632 Page seeded by OCA on Sun May 4 22:52:25 2008
