6qp7

Structural highlights

Function

[SEM2A_DROME] Plays a role in growth cones guidance. Required for both proper adult behavior and survival. Can function in vivo as a selective target-derived signal that inhibits the formation of specific synaptic terminal arbors.^[1]

References

1. ↑ Kolodkin AL, Matthes DJ, Goodman CS. The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules. Cell. 1993 Dec 31;75(7):1389-99. PMID:8269517