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Function
History
Searchers suspected since 70s the existence of diffrents angiotensin receptors. But it was only at the end of 80s that searchers had tools to identify these two distincts transmembrane receptors (AT1R and AT2R)[3]. Three labs discoveredin the same time these two receptors so they were some confusion about the nomenclature. So In 1991 a group of searchers met to make the nomenclature coherent. Finally, around 2015, researchers the crystal structure of the receptor in complex with its antagonist ZD7155 and with an inverse agonist olmesartan [4]. They used x-ray cryogenic-crystallography. They found similar conformation of the receptor when it is link to the antagonist or to the inverse agonist. They also found conserved molecular recognition modes. So to complet the discovery, they realized some experiment with mutants to identify the différents residus which interact with the ligand.
Structure/Function relationship
Application in the therapeutic field
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