Introduction
The ABCG2 multidrug transporter is part of the ATP-binding cassette (ABC) transporter family. Also know as the breast cancer resistance protein (BCRP), ABCG2 has physiological roles in various tissue cells including the mammary gland and the blood-brain, bloodtestis, and maternal-fetal barriers.[1]
Function
Transports xenobiotic molecules out of the cell (molecules that shouldn't be there) to protect cellular tissue
Structural highlights
ATP Bound and Unbound Conformations
Cavities and Lysine Plug
Disease
Cancer
ABCG2 contributes to multidrug resistance in cancer cells by exporting anti-tumor drugs out of cells which is an obstacle in cancer treatment.[1]
brief description of the cancer genes listed in the papers (papers talk about how some cancers had more expression of abcg2 genes)
ABCG2 as a Target for Inhibition
Talk about how and why it would be a good target for the treatment of cancer
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
