Function
Syntaxin (Stx) are membrane-integrated proteins that are instrumental in exocytosis of vesicles.
- Stx-1 is essential for the formation of the SNARE complex involved in the fusion machinery in the brain. Stx-1 forms a 4-helical bundle complex with proteins SNAP-25 and VAMP2 which drives fusion of vesicles with the plasma membrane[1]. The coiled-coil bundle structure is formed by the interactions of the complex SNARE motifs[2].
- Stx-1A regulates the function of transmembrane proteins like ion channels and neurotransmitter transporters[3].
Relevance
The blockade of Stx-1 inhibits glioblastoma tumor growth and may represent a novel therapeutic tool against this fatal tumor[4].
Structural highlights
(PDB code 3hd7). The interactions of the syntaxin 1a and VAMP2 SNARE motives consist of hydrogen bond and polar interactions[5]. (PDB code 3ipd).
3D structures of syntaxin
Syntaxin 3D structures
