Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP)* is a hydrolase enzyme which is known to be expressed in the liver, kidney, and at moderate levels in the brain[1]. It belongs to the haloacid dehalogenase (HAD) superfamily of hydrolases with hydrolyze a wide variety of substrates[2]. LHPP, specifically, hydrolyzes both oxygen-phosphorous bonds in inorganic phosphate and nitrogen-phosphorous bonds in phospholysine*, phosphohistidine*, and imidodiphosphate*. LHPP has been of particular interest to researchers in recent years due to its hypothesized function as a tumor suppressor and thus its role in various cancers[3].
The HAD Superfamily
HAD Phosphatases: Mechanism & Structure
LHPP-Specific Mechanisms & Structure
Role in Disease
Major Depressive Disorder
Cancer
Thyroid Diseases
References
- ↑ Gohla A. Do metabolic HAD phosphatases moonlight as protein phosphatases? Biochim Biophys Acta Mol Cell Res. 2019 Jan;1866(1):153-166. doi:, 10.1016/j.bbamcr.2018.07.007. Epub 2018 Jul 18. PMID:30030002 doi:http://dx.doi.org/10.1016/j.bbamcr.2018.07.007
- ↑ Seifried A, Schultz J, Gohla A. Human HAD phosphatases: structure, mechanism, and roles in health and disease. FEBS J. 2013 Jan;280(2):549-71. doi: 10.1111/j.1742-4658.2012.08633.x. Epub 2012 , Jun 13. PMID:22607316 doi:http://dx.doi.org/10.1111/j.1742-4658.2012.08633.x
- ↑ Hindupur SK, Colombi M, Fuhs SR, Matter MS, Guri Y, Adam K, Cornu M, Piscuoglio S, Ng CKY, Betz C, Liko D, Quagliata L, Moes S, Jenoe P, Terracciano LM, Heim MH, Hunter T, Hall MN. The protein histidine phosphatase LHPP is a tumour suppressor. Nature. 2018 Mar 29;555(7698):678-682. doi: 10.1038/nature26140. Epub 2018 Mar, 21. PMID:29562234 doi:http://dx.doi.org/10.1038/nature26140
