OCT4 and SOX2 transcription factors
From Proteopedia
Introduction
Although they are not obligate heterodimers, the transcriptional factors Sox2 and Oct4 occupy the same target genes in vivo (LA Boyer et al., 2005; X Chen et al., 2008).
OCT4-SOX2 preferential binding to nucleosomal entry-exit sites
The nucleosome is the basic chromosome unit, composed of a 147 pb DNA segment wrapped around eight histone proteins. The nucleosome main axis is referred as "dyad" and the sites in which the DNA starts to wrap and unfold in the nucleosome are called "entry" and "exit" sites. The DNA location around the histones can be defined by the major grove direction. The points in which a major groove is pointed to the nucleosome core is called superhelix location (SHL). The SHL are counted from 0 to ±7, being 0 the dyad position.
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