User:Isabela Fonseca de Oliveira Granha/Sandbox 1

From Proteopedia

Jump to: navigation, search

ß-catenin

ß-catenin is an important element in cell-cell adherens junctions, called cadherins. Reported in all Eukaryota (Eukaryota) phylum, in humans the gene CTNNB1 transcribes a 95kDa protein that allows cadherins to anchor in cytoeskeleton (actin filaments) connecting with cytoplasmic proteins. Besides that, it is an essential regulator of the canonical Wnt pathway [1] (related to embryonic development). Disturbance of this activity is associated with cancer and other diseases. Therefore, ß-catenin is an important target for developing medication for many diseases, with considerable interest in its structure. [2]

Structure of ß-catenin from Zebrafish

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Isabela Fonseca de Oliveira Granha

Personal tools