Function
Limonene-1,2-epoxide hydrolase (LEH) is part of the limonene degradation pathway of Rhodococcus erythropolis. LEH hydrolyzes limonene-1,2-epoxide to produce limonene-1,2-diol[1].
Relevance
LEH plays important physiological role in detoxification of reactive xenobiotics or endogenous metabolites and in the formation of biologically active mediators[2].
Structural highlights
The complex of LEH with the valpromide inhibitor shows the valpromide in the LEH active site forming a . Water molecule is shown as red sphere.In the LEH hydrolysis mechanism [3].
