Structural highlights
Function
PART_SPHYB Toxic component of a type II toxin-antitoxin (TA) system. Expression in E.coli inhibits cell growth; bacteriostasis is neutralized by expression of cognate antitoxin ParS. ADP-ribosylates E.coli ribose-phosphate pyrophosphokinase (RPPK, prs) using NAD(+) in vitro; ADP-ribosylates RPPK on 'Lys-182' and 'Ser-202'. Cannot use NADP(+). Also auto-ADP-ribosylates in vitro; in the presence of RPPK auto-ADP-ribosylation decreases.[1]
References
- ↑ Piscotta FJ, Jeffrey PD, Link AJ. ParST is a widespread toxin-antitoxin module that targets nucleotide metabolism. Proc Natl Acad Sci U S A. 2018 Dec 31. pii: 1814633116. doi:, 10.1073/pnas.1814633116. PMID:30598453 doi:http://dx.doi.org/10.1073/pnas.1814633116
