From Proteopedia
proteopedia linkproteopedia link Mtb Transpeptidase Domain in Complex with Penicillin
| Tuberculosis (TB) is a human respiratory disease which is caused by Mycobacterium Tuberculosis. The infection of M. tuberculosis causes a large area of necrosis of pulmonary tissue, which results in significant breathing difficulties. TB is also known to be a major causing agent for chronic obstructive pulmonary disease (COPD). Nowadays, TB proposes a significant problem in antibiotic resistance, traditional antibiotics gradually become less and less effective towards the antibiotic-resistant strain of M. tuberculosis. In order to develop a novel antibiotic, further research has led us into the mechanism of how known antibiotic acts on M. tuberculosis. A new therapeutic approach is taken by investigating the penicillium binding site PonA1.
Function
Disease
Relevance
Structural highlights
Penicillin V binds to the transpeptidase domain of this protein. , penicillin V is shown as ball and stick, with the carbon atoms in red.
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References
Filippova, E. V., Kieser, K. J., Luan, C. H., Wawrzak, Z., Kiryukhina, O., Rubin, E. J., & Anderson, W. F. (2016). Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin‐binding protein PonA1 reveal potential mechanisms of antibiotic resistance. The FEBS journal, 283(12), 2206-2218.
