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3D Structures of transcriptional activator

Updated on 04-May-2022 - For a general description of the protein see Transcriptional activator {{#tree:id=OrganizedByTopic|openlevels=0|

• Gcn4 TA See Gcn4

• Gcn5 TA

• • 1e6i – yTA brododomain + histone H4 peptide - yeast
    
  • 1ygh – yTA histone acetyltransferase domain
    

• C-Myb TA; domains – DBD ; DBD repeat 1 38-89; repeat 2 90-141; repeat 3 142-193; transcription activation 291-315

• • 1mse, 1msf – mTA DBD 90-193 + DNA – NMR - mouse
    
  • 1mbe]], 1mbf – mTA DBD repeat 1 + DNA - NMR
    
  • [1mbg]], 1mbh – mTA DBD repeat 2 + DNA - NMR
    
  • 1mbj, 1mbk – mTA DBD repeat 3 + DNA - NMR
    
  • 1h88 – mTA DBD + DNA + CCAAT/enhancer binding protein β
    
  • 1h89 – mTA DBD + DNA + CAAT/enhancer binding protein β
    
  • 1guu – mTA DBD repeat 1
    
  • 1gv2 – mTA DBD repeat 2,3
    
  • 1gv5 – mTA DBD repeat 2
    
  • 1gvd – mTA DBD repeat 2 (mutant)
    
  • 1idy, 1idz – mTA DBD repeat 3 (mutant) - NMR
    
  • 1sb0, 2agh – mTA transcription activation domain + CREB-binding protein - NMR
    
  • 6dmx, 6dnq – mTA transcription activation domain + CREB-binding protein p3ptide + Bzip factor
    

• Psp operon TA

• • 2bjw – EcTA AAA domain – Escherichia coli
    

• • 4qnr – EcTA AAA domain (mutant) + ATP
    
  • 4qos – EcTA AAA domain (mutant) + ADP
    
  • 2c98 – EcTA AAA domain + ADP
    
  • 2c99 – EcTA AAA domain + AMPPNP
    
  • 2vii – EcTA AAA domain + AMP + Mg
    
  • 5nss – EcTA in RNA polymerase complex – Cryo EM
    

• TenA TA

• • 1tyh, 1yaf – BsTA – Bacillus subtilis
    
  • 2qzc – TA – Sulfolobus solfataricus
    
  • 3no6 – TA – Staphylococcus epidermidis
    
  • 1yak – BsTA + pyrimidine derivative
    
  • 2qcx – BsTA (mutant) + pyrimidine derivative
    
  • 1udd – TA – Pyrococcus horikishii
    

• LasR TA or transcriptional regulator LasR

• • 6mww – PaTA – Pseudomonas aeruginosa
    
  • 2uv0 – PaTA LBD residues 1-173
    
  • 3ix3, 6mvn, 6mvm – PaTA LBD + oxo-dodecanoyl-homoserine lactone
    
  • 3ix4, 3ix8, 3jpu, 6d6a, 6d6b, 6d6c, 6d6d, **6d6p, 6d6l, 6d6m, 6d6o, 6d6n – PaTA LBD + benzoate derivative
    
  • 6mwl – PaTA + oxothiolan derivative
    
  • 6mwh – PaTA + acetamide derivative
    
  • 4ng2 – PaTA LBD + protein
    
  • 6mwz – PaTA (mutant) + peptide
    
  • 6v7w, 6v7x – PaTA + Aqs1
    

• CadC TA

• • 3ly7, 3lya – EcTA periplasmic domain 188-512
    
  • 3ly8, 3ly9 – EcTA periplasmic domain (mutant)
    
  • 5ju7 – EcTA DBD 2-107
    

• Mal-Rpel TA

• • 2v51, 2v52 – mTA residues 16-41 + actin
    
  • 2yje, 2yjf – mTA Rpel domain + actin
    

Brg1 TA

• • 5ea1 – hTA bromodomain 1418-1536 - human
    
  • 3uvd – hTA bromodomain - NMR
    
  • 2grc, 3uvd, 5dkd, 6zs2 – hTA bromodomain + inhibitor
    
  • 6hr2 – hTA bromodomain + ElonginB + ElonginC + pVHL
    
  • 2i8b – TA C terminal – Zaire ebolavirus
    
  • 3v7o – TA C terminal – Reston ebolavirus
    

• Flagelar TA

• • 1g8e – EcTA FlhD
    
  • 2avu – EcTA FlhC+FLHD
    
  • 5hxg – StTA FlhD + STM1697
    

• Tipa TA

• • 1ny9 – SlTA antibiotic binding domain – Streptomyces lividans - NMR
    
  • 2mbz, 2mc0 - SlTA antibiotic binding domain + thiopeptide - NMR
    

• • 1r8d – BsTA
    

• Rfah TA

• • 2oug – EcTA
    
  • 2lcl – EcTA C terminal - NMR
    
  • 5ond – EcTA + DNA
    

• SoxR TA or redox-sensitive transcriptional activator

• • 2zhh – EcTA
    
  • 2zhg – EcTA + DNA
    
  • 6tf4 – VcTA C terminal - Vibrio cholera - NMR
    

• GlxR TA

• • 3r6s – CgTA +cAMP – Corynebacterium glutamicum
    
  • 4byy – CgTA
    

• OxyR TA or hydrogen peroxide-inducible genes activator

• • 3t22, 3ho7, 3uki – TA regulatory domain – Porphyromonas gingivalis
    
  • 7l4s – TA regulatory domain – Shewnella oneidensis
    
  • 4y0m – PaTA regulatory domain
    
  • 4x6g, 4xws – PaTA regulatory domain (mutant)
    
  • 1i69, 1i6a – EcTA regulatory domain (mutant)
    
  • 6g1d – CgTA regulatory domain (mutant)
    
  • 6g1b, 6g4r – CgTA regulatory domain + H2O2
    
  • 5x0v – VvTA - Vibrio vulnificus
    
  • 5b70, 5b7d, 5b7h, 5x0q – VvTA (mutant)
    
  • 3jv9 – NmTA – Neisseria meningitidis
    

• PlcR TA

• • 4fsc – BtTA - Bacillus thuringiensis
    
  • 2qfc – BtTA + PapR peptide
    
  • 3u3w – BtTA + DNA + PapR peptide
    

• VirB TA or virulence regulon transcriptional activator VirB

• • 3vwb, 3w2a, 3w3c – TA core domain + DNA – Shigella flexneri
    

• MafA TA

• • 4eot – hTA DBD
    

• CysB TA or Cys regulon transcriptional activator CysB

• • 4gwo, 4gxa, 4lon, 4lp2 – StTA C terminal – Salmonella typhimurium
    
  • 4lq2, 4lq5, 4m4g – StTA C terminal + acetylserine
    
  • 1al3 – TA cofactor binding domain – Klebsiella aerogenes
    
  • 5z50 – PaTA regulatory domain
    
  • 5z4y, 5z4z – PaTA NTD domain
    

• HlyU TA

• • 4k2e, 4ooi – VcTA
    
  • 3jth – VvTA
    
  • 5znx – VvTA + inhibitor
    

• ToxR TA

• • 6uue, 6utc – VvTA
    
  • 7nmb, 7nn6 – VcTA - NMR
    

• LysR TA

• • 5x0o – VvTA
    
  • 5x0n – VvTA (mutant)
    
  • 3t1b, 3szp – VcTA
    
  • 6tpr, 6z07, 6z17, 6z5k, 6yz3, 7o2t, 7o2u – PaTA + antagonist
    
  • 6yiz, 7nbw – PaTA + agonist
    
  • 5z7h – SaTA
    
  • 4pzj – TA – Eggerthella lenta
    
  • 3hhf, 3hhg, 4ab5 – NmTA
    
  • 3fzj – TA – Comamonas testosteroni
    
  • 1ixc, 1iz1 – CnTA – Cupriavidus necator
    
  • 5xxp, 7d98 – CnTA + DNA
    
  • 1uth, 2y7r, 5ae4 – TA – Burkholderia cepacia
    
  • 7trv, 7trw – TA LBD – Yersinia pestis
    
  • 7erp, 7erq – CsTA regulatory domain – Cronobacter sakazakii
    
  • 7fdf – CsTA regulatory domain (mutant)
    

• Aft2 TA

• • 4lmg – yTA + DNA
    

• Mga TA

• • 5way – SpTA – Streptococcus pneumoniae
    

• Spt7 TA

• • 6t9k, 6t9i – yTA in SAGA – Cryo EM
    

• Quorum-sensing TA or TraR

• • 5l07 – YeTA – Yersinia enterocolitica
    
  • 5l09 – YeTA + THF derivative
    
  • 1l3l – AtTA + pheromone + DNA – Agrobacterium tumefaciens
    
  • 1h0m – AtTA + auto-inducer + DNA
    

• MexT TA

• • 6l33 – PaTA regulatory domain
    

• ComR TA

• • 5juf, 6qer – StTA – Streptococcus thermophilus
    
  • 5jub – StTA + DNA
    
  • 5fd4 – TA – Streptococcus suis
    
  • 7n10, 7n1n – SmTA DBD + Prx – Streptococcus mutans
    
  • 6hu8 – SvTA – Streptococcus vestibularis
    
  • 6hua – SvTA + peptide
    

• FasR TA

• • 6o6p – MtTA + DNA – Mycobacterium tuberculosis
    
  • 6o6o – MtTA + myristic acid
    
  • 6o6n – MtTA + arachinoyl-CoA
    

• ModE TA

• • 1o7l, 1h9s – EcTA + Mo
    
  • 1b9m, 1b9n, 1h9r – EcTA + Ni
    

• TetR family TA

• • 1z77, 2id6, 2iek, 1zkg, 4i76, 3ih2, 3ih3, 3ih4 – TmTA – Thermotoga maritima
    
  • 4i6z – TmTA + DNA
    
  • 1zk8, 2fq4, 4me9 – BcTA – Bacillus cereus
    
  • 3cwr – TA – Rhodspirillum rubrum
    
  • 1z0x – EfTA – Enterococcus faecalis
    
  • 3c2b – AfTA – Agrobacterium fabrum
    
  • 2o7t – CgTA
    
  • 2g7s – AtTA
    
  • 3gzi – TA – Shewanella loihica
    
  • 2qib, 2zcx, 6srm – ScTA – Streptomyces coelicolor
    
  • 2hyt – TA – Pectobacterium atrosepticum
    
  • 3cdl – PsTA – Pseudomonas syringae
    
  • 3kkc – SaTA – Streptococcus agalactiae
    
  • 3nnr – TA – Marinobacter aquaeolei
    
  • 3on4 – TA – Legionella pneumophila
    
  • 3f1b – RjTA – Rhodococcus jostii
    
  • 3eup – TA – Cytophaga hutchinsonii
    
  • 3egq – TA – Archaeoglobus fulgidus
    
  • 4hku – LmTA – Listeria monocytogenes
    
  • 3nrg, 3qbm – TA – Chlotoflexus aurantiacus
    
  • 6nsr – PaTA (mutant) + DNA
    
  • 4jkz – MsTA – Mycobacterium smegmatis
    
  • 6el2 – SacTA – Sulfolobus acidocaldarius
    
  • 6en8 – SacTA + DNA
    

• TetR/AcrR family TA

• • 2rae – RjTA
    
  • 3lhq – StTA
    
  • 3b81 – CpTA – Clostridium acetobutylicum
    
  • 3dcf – TA – Thermobifida fusca
    
  • 3mvp – SmTA
    
  • 5d18, 5d19, 6a4l, 6a4w – MtTA
    
  • 2eh3 – TA – Aquifex aeolicus
    
  • 3vuq – TtTA – Thermus thermophilus
    
  • 7eqe – SgTA – Streptococcus griseus
    
  • 7eqf – SgTA + ligand
    
  • 5gp9, 5gpa – BhTA – Bacillus halodurans
    
  • 5gpc – BhTA + DNA
    
  • 6g87 – BdTA – Bradyrhizobium diazoefficiens
    
  • 6g8h – BdTA + naringenin
    
  • 6g8g – BdTA + genistein
    

• GntR family TA

• • 3l5z – BcTA
    
  • 3ddv – EfTA
    
  • 3fms, 3sxy – TmTA
    
  • 3c7j – PsTA
    
  • 2di3, 2p19 – CgTA
    
  • 3tqn – TA – Coxiella burnetii
    
  • 6za0, 6za3, 7za7 – AfTA
    
  • 6z74, 6zab – AfTA + DNA
    
  • 7u5q – TA – Brucella melitensis
    
  • 6sbs – SacTA
    
  • 3h5o – TA – Chromobacterium violaceum
    
  • 6az6, 7b5t, 7b5y, 7b5w – SaTA
    
  • 7b5u – SaTA + diAMP
    
  • 7oz3 – SaTA + DNA – Cryo EM
    
  • 4r1h – LmTA
    
  • 3ihu – TA – Ralstonia eutropha
    
  • 3lhe – TA – Bacillus anthracis
    
  • 3f8m – MsTA
    

• MarR family TA or multiple antibiotic resistance protein

• • 3boq, 3cjn, 3e6m – RpTA - Ruegeria pomeryi
    
  • 3s2w – TA – Methanosarcina mazei
    
  • 3bpv – TA – Methanobacterium thermoautotrophicum
    
  • 2fbk – DrTA – Deinococcus radiodurans
    
  • 5dd8 – DrTA (mutant)
    
  • 2fa5 – TA – Xanthomonas campestris
    
  • 3g3z, 5aiq – NmTA
    
  • 5aip – NmTA + hydroxyphenylacetate
    
  • 5e1w – DmTA – Dihalococcoides mccartyi
    
  • 5e1z, 5e1x, 5e20 – DmTA + phenol derivative
    
  • 6c28 – RpTA + coumaroyl-CoA – Rhodopseudomonas palustris
    
  • 3fm5 – RjTA
    
  • 1z91 – BsTA
    
  • 4b8x – ScTA
    
  • 4yif – MtTA
    
  • 3vb2, 3voe, 4jba – EcTA
    
  • 3vod – EcTA (mutant)
    
  • 5h3r – EcTA (mutant) + DNA
    
  • 5eri – CdTA – Clostridium difficile
    
  • 7dvn – TA + effector – Paenisporosarcina
    
  • 3u2r – TA – Planctopirus limnophilus
    
  • 2rdp – TA – Bacillus stearothermophilus
    

• MerR family TA or mercuric resistance operon regulatory protein

• • 3hh0 – BcTA
    
  • 3gpv – BtTA
    
  • 4ua1, 4ua2 – TA – Bacillus megaterium
    
  • 5crl – PaTA
    
  • 5gpe – TA – Cupriavidus metallidurans
    
  • 3cnb – TA – Colwellia psychrerythraea
    
  • 6d90 – HiTA – Haemophilia influenzae
    
  • 5d8c – HiTA + DNA
    
  • 6xl6, 6xla, 6xlk – EcTA + DNA – Cryo EM
    
  • 6xl5, 6xl9, 6xlj – EcTA in RNP complex – Cryo EM
    

• AsnC family TA

• • 3i4p – AfTA
    
  • 2cg4 – EcTA
    

• AraC family TA or arabinose operon regulatory protein

• • 3gra – PpTA – Pseudomonas putida
    
  • 3cu5 – TA – Lacnoclostridium phytofermentans
    
  • 5chh – PaTA
    
  • 2ara – EcTA
    
  • 1xja – EcTA dimerization domain (mutant)
    
  • 2k9s – EcTA DBD - NMR
    
  • 2arc – EcTA + arabinose
    
  • 2aac – EcTA + fucose
    

• LacI family TA

• • 3kjx, 3e3m – RpTA
    
  • 3jy6 – TA - Lactobacillus brevis
    
  • 6chk – LcTA - Lactobacillus casei
    
  • 4rk5, 4rk4 – LcTA + sugar
    
  • 4rk0, 4rk1 – EfTA + ribose
    
  • 3h5t – CgTA
    
  • 3kke – MsTA
    
  • 4rkq, 4rkr – TA - Arthrobacter
    

• PadR family TA

• • 5zhv, 5zi8, 5zhc – MtTA
    
  • 5zqh – SpTA
    
  • 5x12, 7cbv – BsTA
    
  • 5x13, 5y8t – BsTA + coumaric acid
    
  • 5x14 – BsTA + ferulic acid
    
  • 6abq, 6abt – LmTA
    
  • 5dym – CdTA
    

• TrmB TA or tRNA (guanine-N(7)-) methyltransferase

• • 2f5t – TA – Thermococcus litoralis
    
  • 3qph – PfTA + sucrose – Pyrococcus furiosus
    

• IclR TA

• • 1mkm – TmTA
    
  • 2o99, 2o9a – EcTA C-terminal
    
  • 1td5 – EcTA LBD
    
  • 7cuo – TA + hydroxybenzoate – Microbacterium hydrocarbonoxydans
    

• BgaR TA

• • 6nwo – CpTA – Clostridium perfringens
    
  • 6nx3, 6nwj, 6nwm, 6nwh – CpTA + pyranose derivative
    

• SlyA TA

• • 1lj9 – EfTA
    
  • 3qpt – StTA
    
  • 3q5f – StTA + DNA
    
  • 4aih – YpTA – Yersinia pseudotuberculosis
    
  • 4aij, 4aik – YpTA + DNA
    

• CouR TA

• • 5cyv, 6c28 – RjTA + coumaroyl-CoA – Rhodococcus jostii
    
  • 6c9t – RpTA
    
  • 6c2s – RpTA + DNA
    

• CueR TA

• • 1q07, 1q06, 1q05 – EcTA
    

• LuxR TA

• • 6wae – VvTA
    
  • 6wai, 6wah, 6wag, 6waf – VvTA (mutant)
    

• LuxT TA

• • 3b4s, 3ljl – VpTA
    

• ClgR TA or Clp gene regulator

• • 5woq – MsTA
    
  • 3f51, 3f52 – CgTA
    

• LmrR TA

• • 3f8b, 6i8n – LlTA – Lactococcus lactis
    
  • 3f8c, 3f8f – LlTA + drug
    
  • 6vwe, 6do0 – LlTA + Rh complex
    
  • 6r1l – LlTA + Cu + phenanthroline
    
  • [[4zzd] – LlTA + riboflavine
    
  • 6fuu – LlTA + heme
    

• MvfR TA

• • 4jvc, 6z17 – PaTA
    
  • 4jvd, 4jvi, 6q7u, 6q7v, 6tpr, 6yiz, 6yz3, 6z07, **6z17, 6z5k, 7nbw, 7o2t, 7o2u – PaTA + inhibitor
    
  • 6b8a, 6q7w – PaTA LBD 94-295 + inhibitor
    

• HdfR TA

• • 6wn5 – TA – Klebsiella pneumoniae
    

• McbR TA

• • 4p9f – EcTA
    
  • 4ab5 – MnTA
    
  • 4ab6 – MnTA (mutant)
    

• MetR TA

• • 5fo5 – EcTA DBD
    

• YvhJ TA

• • 3nxh – BsTA
    

• CgmR TA

• • 2yve, 2zoy – CgTA
    
  • 2zoz – CgTA + ethidium
    
  • 2yvh – CgTA + DNA
    

• AraR TA or arabinose metabolism transcriptional repressor

• • 5bs6, 5dd4 – BtTA – Bacterioides thetaiotaomicron
    
  • 3tb6 – BtTA effector-binding domain 71-362 + arabinose
    
  • 5ddg – BtTA + DNA
    
  • 5deq – BtTA 1-225 + arabinose
    
  • 4egy, 4egz, 4h0e, 5d4r, 5d4s – BsTA DBD 1-68 + DNA
    

• CarH TA or light-dependent transcriptional regulator

• • 5c8a, 5c8d, 5c8e, 5c8f – TtTA + cobalamin derivative
    

• ZitR TA or zinc transport transcriptional regulator

• • 5yhx – LlTA
    
  • 5yhy, 5yhz, 5yi0, 5yi1, 6fi9 – LlTA (mutant)
    
  • 5yi2 – LlTA + DNA
    
  • 5yi3 – LlTA (mutant) + DNA
    

• LsrR TA

• • 4l4y – EcTA
    
  • 4l4z, 4l50, 4l51, 4l5i, 4l5j – EcTA + ligand
    

• HTH-type TA or helix-turn-helix-type

• • 2uxu – PpTA TtgR + naringenin
    
  • 2uxh – PpTA TtgR + quercetin
    
  • 2uxi – PpTA TtgR + phloretin
    
  • 6ugl, 6kju – VcTA + pyrazine derivative
    
  • 2bv6 – SaTA MgrA – Staphylococcus aureus
    
  • 5hs5, 5ywj, 6k8e – SaTA SarX
    
  • 3hrm, 3hse – SaTA SarZ
    
  • 6r1p – MtTA EthR
    
  • 1ysq – EcTA YiaJ
    
  • 2qop, 3bcg – EcTA AcrR
    
  • 6ldi, 6xh7, 6xh8, 7c17 – EcTA CueR in transcription activation complex – Cryo EM
    
  • 4wls, 4wlw – EcTA CueR + DNA
    
  • 4x1e – EcTA RutR
    
  • 4xk4, 4jyk – EcTA RutR + uracil derivative
    
  • 2hxr – EcTA CynR LBD
    
  • 3hfu – EcTA CynR LBD + N3
    
  • 2gfn – RjTA Rha1
    
  • 1i1g – PfTA LrpA
    
  • 7cla – TA SkgA – Caulobacter vibrioides
    
  • 7bzd – BsTA HxlR
    
  • 7bze – BsTA HxlR (mutant)
    
  • 7bzg – BsTA HxlR + DNA
    
  • 7amn, 7amt – TA LuxR + DNA – Vibrio alginolyticus
    
  • 2dtz, 2hq5 – SaTA QacR (mutant)
    
  • 3bqz, 3br0, 3btc, 3btl – SaTA QacR (mutant) + malachite green
    
  • 3br1, 3br2, 3bt9, 3btj – SaTA QacR (mutant) + dequalinium
    
  • 3bti – SaTA QacR (mutant) + berberine
    
  • 1qvu,3br3, 3pm1 – SaTA QacR (mutant) + ethidium
    
  • 1rkw, 1rpw – SaTA QacR (mutant) + pentamadine
    
  • 1qvt – SaTA QacR (mutant) + proflavine
    
  • 3br5, 3br6 – SaTA QacR (mutant) + rhodamine
    
  • 2gby – SaTA QacR (mutant) + berenil
    
  • 2g0e – SaTA QacR (mutant) + drug
    
  • 3k1n – AbTA BenM – Acinetobacter baylyi
    
  • 3k1p – AbTA BenM (mutant)
    
  • 2f6g, 2f6p, 2f97 – AbTA BenM effector-binding domain 81-304
    
  • 3m1e – AbTA BenM DBD 1-87
    
  • 4ihs, 4iht – AbTA BenM effector-binding domain + DNA
    
  • 2f78, 2f7a, 2f7c – AbTA BenM effector-binding domain + effector
    
  • 2h9b – EfTA BenM (mutant)
    
  • 2f7b, 2h98 – AbTA CatM effector-binding domain
    
  • 3glb – AbTA CatM effector-binding domain (mutant)
    
  • 2f7c – AbTA CatM effector-binding domain + muconate
    
  • 2cfx – BsTA LrpC
    
  • 2gqq – EcTA LrpC
    
  • 6d2s, 6cyj, 6cz6, 6cyy – MtTA PrpR
    
  • 2pju – EcTA PrpR
    
  • 5t4k, 5t4j, 5t4l, 5x03 – BsTA GabR EBO domain + pyridine derivative
    
  • 4mgr, 4nob, 4tv7 – BsTA GabR
    
  • 6uxz – BsTA GabR + agonist
    
  • 5u9e, 5u93 – TA RhaR regulatory domain – Bacteria latreille
    
  • 5z49 – TA CmpR effector-binding domain + ribulose bisphosphate – Synechococcus elongatus
    
  • 3kos – CfTA AmpR effector binding domain – Citrobacter freundii
    
  • 3kot – CfTA AmpR effector binding domain (mutant)
    
  • 4wkm – CfTA AmpR effector binding domain + peptide
    
  • 5mmh – PaTA AmpR effector binding domain
    

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