1a02
From Proteopedia
|
STRUCTURE OF THE DNA BINDING DOMAINS OF NFAT, FOS AND JUN BOUND TO DNA
Contents |
Overview
The nuclear factor of activated T cells (NFAT) and the AP-1 heterodimer, Fos-Jun, cooperatively bind a composite DNA site and synergistically, activate the expression of many immune-response genes. A 2.7-A-resolution, crystal structure of the DNA-binding domains of NFAT, Fos and Jun, in a, quaternary complex with a DNA fragment containing the distal, antigen-receptor response element from the interleukin-2 gene promoter, shows an extended interface between NFAT and AP-1, facilitated by the, bending of Fos and DNA. The tight association of the three proteins on DNA, creates a continuous groove for the recognition of 15 base pairs.
Disease
Known diseases associated with this structure: Autoimmune polyglandular disease, type I OMIM:[607358], Sveinsson choreoretinal atrophy OMIM:[189967]
About this Structure
1A02 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA., Chen L, Glover JN, Hogan PG, Rao A, Harrison SC, Nature. 1998 Mar 5;392(6671):42-8. PMID:9510247
Page seeded by OCA on Mon Nov 12 13:44:28 2007
