User:Hannah Wright/Sandbox 1

From Proteopedia

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=Lipoprotein Lipase (LPL) complexed with GPIHBP1=

spinqualitylabelsall models Lipoprotein Lipase - 6E7K Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Introduction 1.1 History 1.2 Significance 2 Function 2.1 General 2.2 Mechanism 2.3 Active Site 3 Disease 3.1 Mutations 3.1.1 D201V 3.1.2 M404R 4 Relevance 4.1 Hypertriglycerademia 4.2 Drug Relevance 5 Structural highlights 5.1 Overall Structure 5.2 LPL 5.3 GPIHBP1 5.4 Calcium Ion Coordination Introduction History Significance [1] Function General Mechanism Active Site Disease Mutations D201V M404R Hyperlipidemia Relevance Hypertriglycerademia Drug Relevance Structural highlights Overall Structure LPL GPIHBP1 Calcium Ion Coordination

References

1. ↑ Birrane G, Beigneux AP, Dwyer B, Strack-Logue B, Kristensen KK, Francone OL, Fong LG, Mertens HDT, Pan CQ, Ploug M, Young SG, Meiyappan M. Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis. Proc Natl Acad Sci U S A. 2018 Dec 17. pii: 1817984116. doi:, 10.1073/pnas.1817984116. PMID:30559189 doi:http://dx.doi.org/10.1073/pnas.1817984116

Student/Contributors

• Ashrey Burely
• Allison Welz
• Hannah Wright