Structural highlights
Disease
[KCNE2_HUMAN] Familial atrial fibrillation;Romano-Ward syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
Function
[KCNE2_HUMAN] Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KVLTQ1 and elicit a voltage-independent current. May associate with HCN1 and HCN2 and increase potassium current.
Publication Abstract from PubMed
KCNQ1 channels play vital roles in cardiovascular, gastric and other systems. The conductance and dynamics of KCNQ1 could be modulated by different single transmembrane helical auxiliary proteins (such as KCNE1, KCNE2 and others). In this study, detail KCNQ1 function modulations by different regions of KCNE1 or KCNE2 were examined using combinational methods of electrophysiology, immunofluorescence, solution NMR and related backbone flexibility analysis. In the presence of KCNE2 N-terminus, decreased surface expression and consequent low activities of KCNQ1 were observed. The transmembrane domains (TMDs) of KCNE1 and KCNE2 were illustrated to associate with the KCNQ1 channel in different modes: Ile64 in KCNE2-TMD interacting with Phe340 and Phe275 in KCNQ1, while two pairs of interacting residues (Phe340-Thr58 and Ala244-Tyr65) in the KCNQ1/KCNE1 complex. The KCNE1 C-terminus could modulate gating property of KCNQ1, whereas KCNE2 C-terminus had only minimal influences on KCNQ1. All of the results demonstrated different KCNQ1 function modulations by different regions of the two auxiliary proteins.
Differential modulations of KCNQ1 by auxiliary proteins KCNE1 and KCNE2.,Li P, Liu H, Lai C, Sun P, Zeng W, Wu F, Zhang L, Wang S, Tian C, Ding J Sci Rep. 2014 May 15;4:4973. doi: 10.1038/srep04973. PMID:24827085[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Li P, Liu H, Lai C, Sun P, Zeng W, Wu F, Zhang L, Wang S, Tian C, Ding J. Differential modulations of KCNQ1 by auxiliary proteins KCNE1 and KCNE2. Sci Rep. 2014 May 15;4:4973. doi: 10.1038/srep04973. PMID:24827085 doi:http://dx.doi.org/10.1038/srep04973
