2m3a

Structural highlights

Function

KNL2_CAEEL Required for the recruitment of hcp-3, hcp-4, knl-1, bub-1 and lin-53 to kinetochores, kinetochore assembly, chromosome condensation and chromosome segregation in meiosis and mitosis.^{[1] [2]}

References

1. ↑ Maddox PS, Hyndman F, Monen J, Oegema K, Desai A. Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin. J Cell Biol. 2007 Mar 12;176(6):757-63. PMID:17339379 doi:10.1083/jcb.200701065
2. ↑ Lee BC, Lin Z, Yuen KW. RbAp46/48(LIN-53) Is Required for Holocentromere Assembly in Caenorhabditis elegans. Cell Rep. 2016 Mar 1;14(8):1819-28. PMID:26904949 doi:10.1016/j.celrep.2016.01.065