2mx2

Structural highlights

Function

VCIP1_RAT Acts as a deubiquitinating enzyme. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP. Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains.^{[1] [2]}

References

1. ↑ Uchiyama K, Jokitalo E, Kano F, Murata M, Zhang X, Canas B, Newman R, Rabouille C, Pappin D, Freemont P, Kondo H. VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo. J Cell Biol. 2002 Dec 9;159(5):855-66. Epub 2002 Dec 9. PMID:12473691 doi:http://dx.doi.org/10.1083/jcb.200208112
2. ↑ Wang Y, Satoh A, Warren G, Meyer HH. VCIP135 acts as a deubiquitinating enzyme during p97-p47-mediated reassembly of mitotic Golgi fragments. J Cell Biol. 2004 Mar 29;164(7):973-8. Epub 2004 Mar 22. PMID:15037600 doi:http://dx.doi.org/10.1083/jcb.200401010