7dpa

Structural highlights

Function

DOCK5_HUMAN Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829).[UniProtKB:B2RY04]^[1]

See Also

• Dedicator of cytokinesis protein 3D structures
• Rac 3D structures

References

1. ↑ Sanders MA, Ampasala D, Basson MD. DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV. J Biol Chem. 2009 Jan 2;284(1):27-35. PMID:19004829 doi:10.1074/jbc.M808010200