| Observation of Substrate Diffusion and Ligand Binding in Enzyme Crystals using High Repetition Rate Mix-and-Inject Serial Crystallography
Suraj Pandey1
, George Calvey2
, Andrea M. Katz2
, Tek Narsingh Malla 1, Faisal H. M. Koua3 4 , Jose
M. Martin-Garcia4,5, Ishwor Poudyal1
, Jay-How Yang4
, Mohammad Vakili6
, Oleksandr Yefanov3 5 ,
Kara A. Zielinski2
, Saša Bajt7,8, Salah Awel3
, Katerina Dörner6
, Matthias Frank9
, Luca Gelisio3 6 ,
Rebecca Jernigan4
, Henry Kirkwood6
, Marco Kloos6
, Jayanath Koliyadu6
, Valerio Mariani3 7 ,
Mitchell D. Miller10, Grant Mills6
, Garrett Nelson11, Jose L. Olmos Jr.10,11, Alireza Sadri3 8 , Tokushi
Sato6
, Alexandra Tolstikova3
, Weijun Xu10, Abbas Ourmazd1
, John H. C. Spence12 9 , Peter
Schwander1
, Anton Barty7
, Henry N. Chapman3,8,13, Petra Fromme4
, Adrian P. Mancuso6,14 10 ,
George N. Phillips Jr.10,15, Richard Bean6
, Lois Pollack2
, Marius Schmidt1,* [1]
Molecular Tour
References
- ↑ Pandey S, Calvey G, Katz AM, Malla TN, Koua FHM, Martin-Garcia JM, Poudyal I, Yang JH, Vakili M, Yefanov O, Zielinski KA, Bajt S, Awel S, Doerner K, Frank M, Gelisio L, Jernigan R, Kirkwood H, Kloos M, Koliyadu J, Mariani V, Miller MD, Mills G, Nelson G, Olmos JL Jr, Sadri A, Sato T, Tolstikova A, Xu W, Ourmazd A, Spence JCH, Schwander P, Barty A, Chapman HN, Fromme P, Mancuso AP, Phillips GN Jr, Bean R, Pollack L, Schmidt M. Observation of substrate diffusion and ligand binding in enzyme crystals using high-repetition-rate mix-and-inject serial crystallography. IUCrJ. 2021 Sep 9;8(Pt 6):878-895. doi: 10.1107/S2052252521008125. eCollection, 2021 Nov 1. PMID:34804542 doi:http://dx.doi.org/10.1107/S2052252521008125
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