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3D structures of Gp120

Updated on 13-April-2023 {{#tree:id=OrganizedByTopic|openlevels=0|

• Gp120 from HIV-1; Domains – Clade A/E 1-140; outer – 1-181; RHPA 1-216; V1-V2 118-246; V3 296-331; core 1-353; C5 484-506

• • 3dnl, 3dnn, 3dno, 3tgq, 3tgr, 3tgt, 3tih, 5f4u, 6utb, 6utd - Gp120 core
    
  • 5fa2 - Gp120 core (mutant)
    
  • 1meq – GP120 C5 domain – NMR
    
  • 1niz, 1nj0, 2esx, 2esz, 1u6u, 1u6v - GP120 V3 loop – NMR
    
  • 4jpj, 5idl - Gp120 outer domain
    

• Gp120+antibody binary complex

• • 4jb9, 4jpj, 4lsp, 4lsq, 4lsr, 4lsu, 4olu, 4olv, 4olx, 4olz, 4om0, 4om1, 4rx4, 4xmp, 4ydi, 4ydj, 4ydk, 5i9q, 5te6, 5fcu, 5f9w, 5f9o, 5f96, 5cd5, 4xvt, 6oej, 6p8m, 6xcj, 7jks, 7jkt, 7klc, 7kmd, 7n8q - Gp120 Clade A/E + antibody
    
  • 4xnz, 6n1w, 7mep, 7t74, 7t76 - Gp120 Clade A/E + antibody – Cryo EM
    
  • 3u7y, 4jpw, 4yc2, 4ybl, 4s1s, 4s1r, 4s1q, [[6ooej], 6ofi - Gp120 Clade A/E (mutant) + antibody
    
  • 4olw, 4oly, 7sx6, 7sx7 - Gp120 core + antibody
    
  • 3tyg, 4i3r, 4i3s, 5kzc, 5if0, 5ies, 4jpv - Gp120 outer domain + antibody
    
  • 5t33 - Gp120 RHPA + antibody
    
  • 3u2s - Gp120 V1V2 region + antibody PG9
    
  • 3se8, 3se9, 3hi1, 3rjq, 4jkp, 4jm2, 4lss, 4lsv, 4ywg, 4xvs, 3ngb, 4ye4, 4rwy, 4jan, 4lst, 5te7, 5f6j, 5te4, 6bf4, 5wb9, 5w6d, 5ukr, 5uem, 5igx, 4dvr - Gp120 core + antibody
    
  • 3idx, 3idy, 2ny7. 4jdt, 5fyl, 5fec, 6bck, 6oz2, 6oz3 - Gp120 core (mutant) + antibody
    
  • 3mls, 3mlw, 4jo3, 6db5, 6db7 - Gp120 V3 + antibody
    
  • 1qnz - Gp120 V3 + antibody - NMR
    
  • 6cez, 6vbo, 6vbp, 6vbq - Gp120 V2 + antibody
    
  • 7r73, 7r74, 7ri1, 7ri2 - Gp120 core + VHH
    

• Gp120 other binary complex

• • 6v0r, 6vfl, 6vrw, 7l7t, 7l7u 6vfl, 7sc5, 7ska - Gp120 Clade A/E + Gp41 core – Cryo EM
    
  • 7l6o - Gp120 Clade A/E (mutant) + Gp41 core
    
  • 6vl5 - Gp120 Clade A/E + Gp41 core – synthetic - Cryo EM
    
  • 4i54, 7rsx, 7rsy, 7rsz, 7tjo, 7tjp, 8dcq, 8fly, 8flz, 8fm0, 8fm2, 8fm3, 8fm4, 8fm5, 8fm7, 8fm8 - Gp120 Clade A/E + inhibitor
    
  • 4i53, 7rdw, 8f9z - Gp120 core + inhibitor
    
  • 6usw, 8fa0 - Gp120 core (mutant) + inhibitor
    
  • 6l1y - Gp120 core + CD4
    
  • 4rz8, 5f4l, 5f4p, 5f4r - Gp120 core + CD4 mimic
    
  • 4dku, 4dkv - Gp120 core (mutant) + CD4 mimetic
    
  • 4jzw, 4jzz, 4k0a, 4ka2 - Gp120 core + CD4 mimetic miniprotein
    
  • 6one, 6onf, 6onh, 6onv, 6p9n - Gp120 Clade A/E (mutant) + CD4 mimetic
    
  • 3tgs, 4dko, 4dkp, 4dkq, 4dkr, 6ooo - Gp120 core + piperidine derivative
    
  • 5u6e - Gp120 core + pyrrole derivative
    
  • 4dvx, 4dvw, 4dvv, 4dvt, 4dvs, 6usw - Gp120 core (mutant) + piperazine derivative
    
  • 6ut1 - Gp120 core (mutant) + inhibitor
    

• Gp120 higher complex

• • 5kjr, 6mfp - Gp120 Clade A/E + M48U1 peptide + antibody
    
  • 4rfo, 4rfn, 6mg7 - Gp120 Clade A/E 4-492 (mutant) + M48U1 peptide + antibody
    
  • 2qad, 3lqa, 4h8w - Gp120 Clade A/E + CD4 + antibody
    
  • 4tvp, 6v6w, 7ucf - Gp120 Clade A/E + Gp41 core + antibody
    
  • 6mpg, 6n1v, 6nfc, 6x96, 6x97, 7kde, 7lg6, 7lu9, 7lxm, 7lxn, 7ly9, 7mdt, 7mdu, 7mxe, 7pc2, 7rsn, 7rso, 7sd3, 7tfn, 7tfo, 7ugn, 7ugp, 7ugq, 7zlk, 8fis - Gp120 Clade A/E + Gp41 core + antibody – Cryo EM
    
  • 6x98, 6ot1, 7n28 - Gp120 Clade A/E (mutant) + Gp41 core + antibody – Cryo EM
    
  • 3jwd, 3jwo, 2i5y, 2i60 - Gp120 core + hCD4 N terminal + antibody
    
  • 2nxy, 2nxz, 2ny0, 2ny1, 2ny2, 2ny3, 2ny4, 2ny5, 2ny6, 1gc1, 1g9m, 1g9n, 1rzj, 1rzk, 1yyl, 1yym, 2b4c - Gp120 core (mutant) + hCD4 N terminal + antibody
    
  • 5a8h, 5a7x, 4rqs, 4r4h, 4r2g, 4p9h - Gp120 core + hCD4 D1-D2 domain + antibody
    
  • 4laj - Gp120 core + CD4 mimetic miniprotein + antibody
    
  • 5w4l, 5uwe, 6w4m - Gp120 core (mutant) + CD4 mimetic peptide + antibody
    
  • 4r4f, 4r4n - Gp120 core + M48U1 peptide + antibody
    
  • 5v8l, 5v8m, 5uty, 5utf, 5um8, 5jsa, 5js9, 5i8h, 5d9q, 5cjx, 5c7k, 6mft, 6mdt, 6mco, 6d2p, 6ck9, 6ch9, 6ch8, 6ch7, 6wix - Gp120 core + Gp41 + antibody
    
  • 6ccb, 6x5b, 6x9r, 6x9s, 6x9t, 6x9u, 6x9v - Gp120 29-504 (mutant) + Gp41 + antibody
    
  • 6cde, 6cdi, 6okp, 6e5p, 6cuf, 6cue, 6chb, 5u1f, 5thr, 4cc8, 3j70, 6udk, 6v8z, 6vlr, 6vo1, 6vtt, 7lo6, 7mxd, 7ugo - Gp120 core + Gp41 + antibody – Cryo EM
    
  • 6mn7, 6nqd, 6olp, 6orn, 6oro, 6orp, 6orq, 6pw6, 6u59, 6uda, 6ulc, 6um6, 6um7, 6v8x, 6vi0, 6vo0, 6vo3, 6vtt, 6vy2, 7l86, 7l87, 7l88, 7l89, 7l8a, 7l8b, 7l8c, 7l8d, 7l8s, 7l8t, 7l8u, 7l8w, 7l8x, 7l8y, 7l8z, 7l90, 7ll1, 7ll2, 7llk, 7lua - Gp120 29-508 + Gp41 + antibody – Cryo EM
    
  • 6nc2, 6nc3 - Gp120 29-508 (mutant) + Gp41 + antibody – Cryo EM
    
  • 5fyk, 5fyj, 4nco, 6nnj, 6nnf, 6nm6 - Gp120 core (mutant) + Gp41 + antibody
    
  • 3j5m - Gp120 core (mutant) + Gp41 + antibody – Cryo EM
    
  • 6u0l, 6u0n, 8d5c - Gp120 32-505 + Gp41 + antibody + CD4 – Cryo EM
    
  • 6um5 - Gp120 30-489 + Gp41 + antibody + CH848 – Cryo EM
    
  • 6vpx, 7lok - Gp120 core + Gp41 + antibody + peptide – Cryo EM
    

• Gp120 from HIV-2 binary complex

• • 5fec, 5cay - Gp120 core (mutant) + CD4
    

• Gp120 from SIV

• • 2bf1, 3fus - Gp120 core
    
  • 3jcc, 3jcb - Gp120 core + CD4 + antibody – Cryo EM
    
  • 7t2p, 8dua - Gp120 + Gp41 core + antibody – Cryo EM
    

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