1cmi

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Image:1cmi.gif

1cmi, resolution 2.5Å

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STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE

Contents

Overview

The structure of the protein known both as neuronal nitric oxide synthase inhibitory protein, PIN (protein inhibitor of nNOS), and also as the 8 kDa dynein light chain (LC8) has been solved by X-ray diffraction. Two PIN/LC8 monomers related by a two-fold axis form a rectangular dimer. Two pairs of alpha-helices cover opposite faces, and each pair of helices packs against a beta-sheet with five antiparallel beta-strands. Each five-stranded beta-sheet contains four strands from one monomer and a fifth strand from the other monomer. A 13-residue peptide from nNOS is bound to the dimer in a deep hydrophobic groove as a sixth antiparallel beta-strand. The structure provides key insights into dimerization of and peptide binding by the multifunctional PIN/LC8 protein.

Disease

Known diseases associated with this structure: Colorectal cancer, somatic OMIM:[604258], Esophageal cancer OMIM:[604050], Lung cancer OMIM:[604050]

About this Structure

1CMI is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1B1W. Full crystallographic information is available from OCA.

Reference

Structure of the PIN/LC8 dimer with a bound peptide., Liang J, Jaffrey SR, Guo W, Snyder SH, Clardy J, Nat Struct Biol. 1999 Aug;6(8):735-40. PMID:10426949

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