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The Centrosomal Protein of 170 kDa (CEP170) is encoded by the gene CEP170, previously known as AKAA0470 [ref 1995].
The gene gives rise to 3 splice varients: CEP170α, CEP170β, and CEP170γ.
The gene is expressed in a variety of tissues https://gtexportal.org/home/gene/CEP170
There are 2 3D models
4jon: Through X-ray Crystalografi
Q5SW79: Predicted protein
Function
Microtubule organization
Microtubule nucleation
Protein-Protein Interactions
- CHEK1 and circCHEK1_246aa
Through Co-IP [1]and MS[2] CEP170 was identified as a putative interactor with CHEK1, further confirmed with Co-IP in cells overexpressing CHEK1 [3]
CHEK and circCHEK1_246aa (isoform from a cRNA) phosphorylate the residue of CEP170, which results in chromosomal instability seen in multiple myeloid cells.
Structural highlights
Disease
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
