Giardiasis or traveler's diarrhea can be fatal to the young, elderly, or immunocompromised. The Seattle Structural Genomics Center for Infectious Disease (SSGCID) has determined the structures of potential drug targets from Giardia lamblia. Some of these proteins are hypothetical proteins that share < 30% sequence identity or less to proteins with known structure.
conformation and
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residues together, and an
between the two states. Putative new hydrogen bonds were added.
Despite the low sequence similarity the hypothetical protein is a prototypical YjgF/YER057c/UK114 endoribonuclease
