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3D structures of purine nucleoside phosphorylase

Updated on 04-October-2023 {{#tree:id=OrganizedByTopic|openlevels=0|

• Purine nucleoside phosphorylase

• • 1ula, 1m73 – hPNP – human
    
  • 1pbn – bPNP – bovine
    
  • 1odk, 1odl – TtPNP – Thermus thermophilus
    
  • 1z33 – TvPNP – Trichomonas vaginalis
    
  • 1tcv, 1td1, 5cxs, 5cxq – SmPNP – Schistosoma mansoni
    
  • 2b94 – PNP – Plasmodium knowlesi
    
  • 4mar – MrPNP – Meiothermus ruber
    
  • 1ecp, 1oty, 1ou4, 1yqq, 1yqu, 1yr3, 3onv, 4rj2, 4ts3, 4ts9 – EcPNP – Escherichia coli
    
  • 1otx, 1oum, 1ov6, 3opv, 4tta, 4tti, 4ttj – EcPNP (mutant)
    
  • 1vhj – VcPNP – Vibrio cholerae
    
  • 1xe3 – PNP – Bacillus anthracis
    
  • 4d8v, 4d8x, 4d8y, 4d98 – BsPNP – Bacillus subtilis
    
  • 3tl6 – EhPNP – Entamoeba histolica
    
  • 3uav, 7fbg – BcPNP – Bacillus cereus
    
  • 4lkr – PNP – Shewanella oneidensis
    
  • 4tym – PNP – Streptococcus agalactiae
    
  • 8d38 – PNP – Geobacillus Stearothermophilus
    

• Purine nucleoside phosphorylase binary complex with phosphate

• • 4gka – hPNP (mutant) + phosphate
    
  • 1a9o, 3pnp, 4pnp – bPNP + phosphate
    
  • 1qe5 – CePNP + phosphate - Cellulomonas
    
  • 1tcu – SmPNP + phosphate
    
  • 3khs – PNP + phosphate – grouper iridovirus
    
  • 4m3n – MrPNP + phosphate
    
  • 3ooe, 3ooh – EcPNP + phosphate
    
  • 4ldn – PNP + phosphate – Vibrio fischeri
    
  • 4m7w – PNP + phosphate – Leptotrichia buccalis
    
  • 5mx4, 5mx6, 5mx8, 5lu0 - HpPNP + phosphate - Helicobacter pylori
    
  • 6aqu – PfPNP + phosphate – Plasmodium falciparum
    
  • 3emv – PNP + phosphate – Plasmodium vivax
    

• Purine nucleoside phosphorylase complex with guanine and guanine derivatives

• • 1ulb, 1v2h – hPNP + guanine
    
  • 4ece – hPNP (mutant) + guanine
    
  • 1rfg – hPNP + guanosine
    
  • 1yry, 3iny – hPNP + guanine derivative
    
  • 1pwy, 1v41, 1v45 – hPNP + antiviral drug
    
  • 1v48, 2ai1, 2ai3, 3fuc – bPNP + guanine derivative
    
  • 1b8n – bPNP + guanine derivative + phosphate
    
  • 3e9z – SmPNP + guanine derivative
    
  • 3iex – SmPNP + guanosine
    
  • 1odj – TtPNP + guanosine
    
  • 4da0, 4da8, 4dae – BsPNP + guanosine derivative
    
  • 1vmk – PNP + guanine – Thermotoga maritima
    
  • 3iom – MtPNP + guanine derivative - Mycobacterium tuberculosis
    
  • 5i3c - EcPNP + guanine derivative
    
  • 1c3x – CePNP + guanine derivative + phosphate
    

• Purine nucleoside phosphorylase complex with inosine and inosine derivatives

• • 1rct – hPNP + inosine
    
  • 1v3q – hPNP + anti HIV drug
    
  • 1a9q, 1a9s – bPNP + inosine
    
  • 2ai2 – bPNP + inosine derivative
    
  • 1a9t, 1a9p, 4pnp – bPNP + deazainosine + phosphate
    
  • 3faz – SmPNP + inosine
    
  • 5tbv – SmPNP + tubercidine
    
  • 5tbt – SmPNP + cytidine
    
  • 1z38 – TvPNP + inosine
    
  • 3uax – BcPNP + inosine
    
  • 2bsx – PfPNP + inosine
    
  • 1z39 – TvPNP + deoxyinosine
    
  • 1pr0 - EcPNP + inosine + phosphate
    

• Purine nucleoside phosphorylase complex with xanthine and xanthine derivatives

• • 1pf7, 1rr6, 1rsz, 1rt9, 3k8o, 3k8q – hPNP + transition state analog
    
  • 2on6 – hPNP (mutant) + transition state analog
    
  • 2a0w, 2a0x, 2a0y, 2oc4, 2oc9 – hPNP (mutant) + hypoxanthine derivative
    
  • 2q7o, 3phb – hPNP + transition state analog + phosphate
    
  • 4ear, 4eb8 – hPNP (mutant) + transition state analog + phosphate
    
  • 1vfn, 1a9r – bPNP + hypoxanthine
    
  • 1b8o, 1g2o – bPNP + hypoxanthine derivative + phosphate
    
  • 3bgs – bPNP + transition state analog + phosphate
    
  • 3fnq, 5tbu – SmPNP + hypoxanthine
    
  • 4dab – BsPNP + hypoxanthine
    
  • 4uc0 – PNP + hypoxanthine – Agrobacterium vitis
    
  • 5ifk - PNP + hypoxanthine - Kluyveromyces lactis
    
  • 3enz – PfPNP + hypoxanthine + ribose + arsenate
    
  • 5iu6 - EcPNP + hypoxanthine derivative
    
  • 3odg – YpPNP + xanthine – Yersinia pseudotuberculosis
    
  • 3mb8 – PNP + transition state analog + phosphate – Toxoplasma gondii
    
  • 3scz – MtPNP + hypoxanthine
    
  • 1n3i – MtPNP + deazahypoxanthine + phosphate
    
  • 1i80 – MtPNP + iminoribitol + deazahypoxanthine + phosphate
    

• Purine nucleoside phosphorylase complex with adenine and adenine derivatives

• • 3ggs – hPNP (mutant) + adenosine derivative
    
  • 1odi – TtPNP + adenosine
    
  • 1z34, 1z35, 1z37 – TvPNP + adenosine derivative
    
  • 4ns1 – PgPNP + adenosine derivative – Porphyromonas gingivalis
    
  • 4nsn – PgPNP + adenine
    
  • 3e9r, 5tbs – SmPNP + adenine
    
  • 3f8w – SmPNP + adenosine
    
  • 4dao – BsPNP + adenine
    
  • 1vhw – VcPNP + adenosine
    
  • 3u40 – EhPNP + adenosine
    
  • 4d9h – BsPNP + adenosine
    
  • 4dan – BsPNP + adenosine derivative
    
  • 2ac7, 3uaw – BcPNP + adenosine
    
  • 3uay, 3uaz – BcPNP (mutant) + adenosine
    
  • 4m1e – PNP + adenine – Planctomyces limnophilus
    
  • 4lna – PNP + adenine + phosphate – Spirosoma linguale
    
  • 1pk7 - EcPNP + adenosine + phosphate
    
  • 1pk9, 1pke, 1pr5, 1pr6, 1pw7 - EcPNP + adenosine derivative + phosphate
    

• Purine nucleoside phosphorylase complex with purine and purine derivatives

• • 3gb9 – hPNP (mutant) + purine derivative
    
  • 1lv8, 1lvu, 2qpl – bPNP + purine derivative
    
  • 1fxu – bPNP + purine derivative + phosphate
    
  • 1ovg - EcPNP (mutant) + purine derivative
    
  • 1pr2, 1pr4 – EcPNP + purine derivative + phosphate
    

• Other purine nucleoside phosphorylase complexes

• • 3d1v – hPNP + mercapto-quinazolinone
    
  • 7zsl, 7zsm, 7zsn, [[7zso, 7zsp, 7zsq, 7zsr – hPNP + inhibitor
    
  • 5etj, 5ugf - hPNP (mutant) + inhibitor + phosphate
    
  • 1z36 – TvPNP + antibiotic
    
  • 2i4t, 2isc – TvPNP + inhibitor + phosphate
    
  • 3e0q – SmPNP + pyrimidine derivative
    
  • 3fb1 – SmPNP + ribose-1-phosphate
    
  • 6awe, 6axa, 6b2l, 6b37, 6b3l, 6b4q, 6b4t, 6b56, 6b6k, 6b71, 6b7i, 6bb7, 6bfv, 6bhb, 6bi1, 6bi9, 6bif, 6bj6, 6bj7, 3djf – SmPNP + inhibitor
    
  • 5ko5 - SmPNP + cytosine
    
  • 5ko6 - SmPNP + cytosine + ribose-1-phosphate
    
  • 1a69, 1pr1 – EcPNP + formycin
    
  • 1k9s, 3ut6 – EcPNP + formycin derivative + phosphate
    
  • 7f3v, 7w1g – EcPNP (mutant) + UDP derivative + phosphate
    
  • 3fow, 6aqs – PfPNP (mutant) + inhibitor + phosphate
    
  • 5znc, 5zni – PfPNP + quinine derivative + phosphate
    
  • 1nw4 – PfPNP + inhibitor + sulfate
    
  • 3phc – PfPNP + inhibitor + phosphate
    
  • 2p4s – PNP + inhibitor + phosphate – Anopheles gambiae
    
  • 3occ – YpPNP + inhibitor + phosphate
    
  • 3of3 – VcPNP + inhibitor + phosphate
    
  • 4da6, 4da7, 4dar – BsPNP + drug
    
  • 3ix2 – MtPNP + drug
    
  • 8c25 – MtPNP + inhibitor
    

• PNP DeoD-type

• • 6f5a, 6f5i, 6g7x – HpPNP
    
  • 6f4w, 6f4x, 6f52 – HpPNP + formycin
    
  • 7ooy, 7ooz, 7op9, 7opa – HpPNP + purine derivative
    
  • 6xz2 – EcPNP (mutant) + formycin
    

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