Structural highlights
Function
IPA7_SHIFL E3 ubiquitin ligase effector protein that interferes with host's ubiquitination pathway (PubMed:30872533). Functions to alter host cell physiology and promote bacterial survival in host tissues (PubMed:30872533). Catalyzes ubiquitination of mouse Nlrp1b allele 1 protein, releasing the cleaved C-terminal part of Nlrp1b, which polymerizes and forms the Nlrp1b inflammasome followed by host cell pyroptosis (PubMed:30872533).[1]
References
- ↑ Sandstrom A, Mitchell PS, Goers L, Mu EW, Lesser CF, Vance RE. Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes. Science. 2019 Apr 5;364(6435):eaau1330. doi: 10.1126/science.aau1330. Epub 2019 , Mar 14. PMID:30872533 doi:http://dx.doi.org/10.1126/science.aau1330
