Structural highlights
Function
[TACAN_HUMAN] Ion channel involved in sensing mechanical pain. Contributes to mechanosensitive currents in nocireceptors and detecting mechanical pain stimuli (By similarity). May also be required for efficient adipogenesis (PubMed:26024229).[UniProtKB:Q8C1E7][1]
Publication Abstract from PubMed
TACAN is an ion channel-like protein that may be involved in sensing mechanical pain. Here, we present the cryo-electron microscopic structure of human TACAN (hTACAN). hTACAN forms a dimer in which each protomer consists of a transmembrane globular domain (TMD) containing six helices and an intracellular domain (ICD) containing two helices. Molecular dynamic simulations suggest that each protomer contains a putative ion conduction pore. A single-point mutation of the key residue Met207 greatly increases membrane pressure-activated currents. In addition, each hTACAN subunit binds one cholesterol molecule. Our data show the molecular assembly of hTACAN and suggest that wild-type hTACAN is in a closed state.
Cryo-EM structure of the human TACAN in a closed state.,Chen X, Wang Y, Li Y, Lu X, Chen J, Li M, Wen T, Liu N, Chang S, Zhang X, Yang X, Shen Y Cell Rep. 2022 Mar 1;38(9):110445. doi: 10.1016/j.celrep.2022.110445. PMID:35235791[2]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Batrakou DG, de Las Heras JI, Czapiewski R, Mouras R, Schirmer EC. TMEM120A and B: Nuclear Envelope Transmembrane Proteins Important for Adipocyte Differentiation. PLoS One. 2015 May 29;10(5):e0127712. doi: 10.1371/journal.pone.0127712., eCollection 2015. PMID:26024229 doi:http://dx.doi.org/10.1371/journal.pone.0127712
- ↑ Chen X, Wang Y, Li Y, Lu X, Chen J, Li M, Wen T, Liu N, Chang S, Zhang X, Yang X, Shen Y. Cryo-EM structure of the human TACAN in a closed state. Cell Rep. 2022 Mar 1;38(9):110445. doi: 10.1016/j.celrep.2022.110445. PMID:35235791 doi:http://dx.doi.org/10.1016/j.celrep.2022.110445
