7qwv

Structural highlights

Function

RE114_MOUSE Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination (PubMed:20551173, PubMed:27723721). Probably acts by forming a complex with IHO1/CCDC36 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis (PubMed:27723721).^{[1] [2]}

References

1. ↑ Kumar R, Bourbon HM, de Massy B. Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice. Genes Dev. 2010 Jun 15;24(12):1266-80. doi: 10.1101/gad.571710. PMID:20551173 doi:http://dx.doi.org/10.1101/gad.571710
2. ↑ Stanzione M, Baumann M, Papanikos F, Dereli I, Lange J, Ramlal A, Trankner D, Shibuya H, de Massy B, Watanabe Y, Jasin M, Keeney S, Toth A. Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice. Nat Cell Biol. 2016 Nov;18(11):1208-1220. doi: 10.1038/ncb3417. Epub 2016 Oct 10. PMID:27723721 doi:http://dx.doi.org/10.1038/ncb3417