Structural highlights
Function
VIN3_ARATH Plays a central role in vernalization by mediating the initial transcriptional repression of the homeotic gene FLC, a floral repressor, after a cold treatment. However, due to its transient expression, it cannot maintain repression of FLC, which is then maintained by Polycomb Group complexes containing VRN2 throughout development. Required to deacetylate histones on the FLC promoter. Together with VIL1, required during vernalization for the modifications of FLC and FLM chromatin that are associated with an epigenetically silenced state (e.g. chromatin modifications, histone deacetylation, and trimethylated H3 'Lys-4' H3K4me3 and 'Lys-27' H3K27me3) and with acquisition of competence to flower.[1] [2] [3]
References
- ↑ Sung S, Amasino RM. Vernalization in Arabidopsis thaliana is mediated by the PHD finger protein VIN3. Nature. 2004 Jan 8;427(6970):159-64. PMID:14712276 doi:http://dx.doi.org/10.1038/nature02195
- ↑ Sung S, Schmitz RJ, Amasino RM. A PHD finger protein involved in both the vernalization and photoperiod pathways in Arabidopsis. Genes Dev. 2006 Dec 1;20(23):3244-8. doi: 10.1101/gad.1493306. Epub 2006 Nov 17. PMID:17114575 doi:http://dx.doi.org/10.1101/gad.1493306
- ↑ Greb T, Mylne JS, Crevillen P, Geraldo N, An H, Gendall AR, Dean C. The PHD finger protein VRN5 functions in the epigenetic silencing of Arabidopsis FLC. Curr Biol. 2007 Jan 9;17(1):73-8. Epub 2006 Dec 14. PMID:17174094 doi:http://dx.doi.org/S0960-9822(06)02570-X
