Background
Ligands
Significance
Structure
Heterotrimeric G-Protein Structure
Novel Characteristics
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PIF/LLF Motif
DRY/ ERC Motif
MRGPRX2 has an rather than the typically conserved DRY Motif.
Sodium Site
The MRGPRX2 consists of Asp-75 and Gly-116 compared to the previously conserved residues in this binding pocket.
Disulfide Bonds
Further Information
NPxxY Motif
The residue is pivotal for receptor activation in all Class A GPCRs.
Function
Before Activation
After Activation
Clinical Relevance
3D Structures
References