This is a default text for your page Michael O'Shaughnessy/ TS. Click above on edit this page to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
[3]
Overview
The enzyme thymidylate synthase catalyzes the transfer of a methyl group and a hydride from 5,10-methylenetetrahydrofolate to 2-deoxyuridine-5'-monophosphate, resulting in the formation of thymidine 5'-monophosphate and dihydrofolate. This is the only de novo source of dTMP in humans.
2-deoxyuridine-5'-monophosphate(dUMP) + 5, 10-methylenetetrahydrofolate(CH2H4F) ⇌ thymidine 5'-monophosphate(dTMP) + Dihydrofolate(H2F)
Small Molecules
2-deoxyuridine-5'-monophosphate(dUMP)
5,10-methylenetetrahydrofolate(CH2H4F)
thymidine 5'-monophosphate(dTMP)
Dihydrofolate(H2F)
Mechanism
Function
Disease
Relevance
Structural highlights
The active site Cysteine has two .
