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Structural Description
NKX2.5 belongs to the NK2-family of homeodomain transcription factors. These
homeodomain proteins function to regulate the transcription of genes important for development.
Proteins in the NK2-family regulate the development of structures through DNA binding at an
endogenous site. These proteins are classified by the conservation of Try54, which is essential
for promoter site recognition. The NK2-family also includes a C-terminal regulatory domain.
NKX2.5 is of particular interest as it has been shown to mediate carcinogenesis.
Protein / DNA Interactions
Scene
Mutational Analysis
Protein / DNA interactions
Clinical Relevance
Structural highlights
