7r85

Structural highlights

Function

AGRB1_MOUSE Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (PubMed:17960134). Also mediates the binding and engulfment of Gram-negative bacteria (PubMed:21245295, PubMed:26838550, PubMed:26838550). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (By similarity). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (By similarity). Promotes myoblast fusion (PubMed:23615608). Activates the Rho pathway in a G-protein-dependent manner (By similarity). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (PubMed:25751059). Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (By similarity).[UniProtKB:C0HL12][UniProtKB:O14514]^{[1] [2] [3] [4] [5] [6]} Inhibits angiogenesis in a CD36-dependent manner.[UniProtKB:O14514] Inhibits angiogenesis.[UniProtKB:O14514]

References

1. ↑ Duda DG, Sunamura M, Lozonschi L, Yokoyama T, Yatsuoka T, Motoi F, Horii A, Tani K, Asano S, Nakamura Y, Matsuno S. Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis. Br J Cancer. 2002 Feb 1;86(3):490-6. doi: 10.1038/sj.bjc.6600067. PMID:11875720 doi:http://dx.doi.org/10.1038/sj.bjc.6600067
2. ↑ Park D, Tosello-Trampont AC, Elliott MR, Lu M, Haney LB, Ma Z, Klibanov AL, Mandell JW, Ravichandran KS. BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature. 2007 Nov 15;450(7168):430-4. PMID:17960134 doi:http://dx.doi.org/nature06329
3. ↑ Das S, Owen KA, Ly KT, Park D, Black SG, Wilson JM, Sifri CD, Ravichandran KS, Ernst PB, Casanova JE. Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2136-41. doi:, 10.1073/pnas.1014775108. Epub 2011 Jan 18. PMID:21245295 doi:http://dx.doi.org/10.1073/pnas.1014775108
4. ↑ Hochreiter-Hufford AE, Lee CS, Kinchen JM, Sokolowski JD, Arandjelovic S, Call JA, Klibanov AL, Yan Z, Mandell JW, Ravichandran KS. Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion. Nature. 2013 May 9;497(7448):263-7. doi: 10.1038/nature12135. Epub 2013 Apr 24. PMID:23615608 doi:http://dx.doi.org/10.1038/nature12135
5. ↑ Zhu D, Li C, Swanson AM, Villalba RM, Guo J, Zhang Z, Matheny S, Murakami T, Stephenson JR, Daniel S, Fukata M, Hall RA, Olson JJ, Neigh GN, Smith Y, Rainnie DG, Van Meir EG. BAI1 regulates spatial learning and synaptic plasticity in the hippocampus. J Clin Invest. 2015 Apr;125(4):1497-508. doi: 10.1172/JCI74603. Epub 2015 Mar 9. PMID:25751059 doi:http://dx.doi.org/10.1172/JCI74603
6. ↑ Billings EA, Lee CS, Owen KA, D'Souza RS, Ravichandran KS, Casanova JE. The adhesion GPCR BAI1 mediates macrophage ROS production and microbicidal activity against Gram-negative bacteria. Sci Signal. 2016 Feb 2;9(413):ra14. doi: 10.1126/scisignal.aac6250. PMID:26838550 doi:http://dx.doi.org/10.1126/scisignal.aac6250