Structural highlights
3rqt is a 1 chain structure with sequence from Staphylococcus aureus subsp. aureus NCTC 8325. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 1.5Å |
| Ligands: | , , , , |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
NIKA_STAA8 Part of the ABC transporter complex NikABCDE (Opp2) involved in nickel import. Binds nickel and transfers it to the membrane-bound permease. Required for full urease activity and plays a significant role in the virulence of S.aureus during urinary tract infection (UTI) (PubMed:20662775). May bind nickel via a nickel-chelator (PubMed:25611161).[1] [2]
References
- ↑ Hiron A, Posteraro B, Carriere M, Remy L, Delporte C, La Sorda M, Sanguinetti M, Juillard V, Borezee-Durant E. A nickel ABC-transporter of Staphylococcus aureus is involved in urinary tract infection. Mol Microbiol. 2010 Sep;77(5):1246-60. doi: 10.1111/j.1365-2958.2010.07287.x. PMID:20662775 doi:http://dx.doi.org/10.1111/j.1365-2958.2010.07287.x
- ↑ Lebrette H, Borezee-Durant E, Martin L, Richaud P, Boeri Erba E, Cavazza C. Novel insights into nickel import in Staphylococcus aureus: the positive role of free histidine and structural characterization of a new thiazolidine-type nickel chelator. Metallomics. 2015 Jan 22. PMID:25611161 doi:http://dx.doi.org/10.1039/c4mt00295d
